Wilson was Cassandra in this ep, foretelling of doom and not believed.

I disagree that he was self-righteous in this ep (we've seen him be that before, for sure). He wasn't holding himself up as a better example; he was simply telling House what he had to do. And he knew House could do it, because House did it for Wilson. Wilson escorting House into Cuddy's patient room would have been just as much a crutch as vicodin. House needed to be able to take that step by himself, and he couldn't. It's horribly sad.